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Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study.

Neurology - 1 Aug 2017

Larsson Susanna C, Scott Robert A, Traylor Matthew, Langenberg Claudia C, Hindy George, Melander Olle, Orho-Melander Marju, Seshadri Sudha, Wareham Nicholas J, Markus Hugh S

Abstract excerpt

OBJECTIVE: To implement a mendelian randomization (MR) approach to determine whether type 2 diabetes mellitus (T2D), fasting glucose, fasting insulin, and body mass index (BMI) are causally associated with specific ischemic stroke subtypes. METHODS: MR estimates of the association between each possible risk factor and ischemic stroke subtypes were calculated with inverse-variance weighted (conventional) and...

Topics

Biomarkers
Blood Glucose
Body Mass Index
Brain Ischemia
Diabetes Mellitus, Type 2
Fasting
Humans
Insulin
Mendelian Randomization Analysis
Odds Ratio
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Regression Analysis

Risk Factors

Stroke

Source

Open in PubMed Open full text

Identifiers

PMID: 28667182
DOI: 10.1212/WNL.0000000000004173
PMCID: PMC5539736

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