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Article

Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies.

Journal of the American Heart Association - 17 Oct 2023

Georgiou Andrea N, Zagkos Loukas, Markozannes Georgios, Chalitsios Christos V, Asimakopoulos Alexandros G, Xu Wei, Wang Lijuan, Mesa-Eguiagaray Ines, Zhou Xuan, Loizidou Eleni M, Kretsavos Nikolaos, Theodoratou Evropi, Gill Dipender, Burgess Stephen, Evangelou Evangelos, Tsilidis Konstantinos K, Tzoulaki Ioanna

Abstract excerpt

BACKGROUND Mendelian randomization (MR) offers a powerful approach to study potential causal associations between exposures and health outcomes by using genetic variants associated with an exposure as instrumental variables. In this systematic review, we aimed to summarize previous MR studies and to evaluate the evidence for causality for a broad range of exposures in relation to coronary artery disease and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37804188
DOI: 10.1161/JAHA.122.029040
PMCID: PMC7615320

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