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Article

Exploiting pleiotropy to enhance variant discovery with functional false discovery rates.

Nature computational science - 1 Sept 2025

Bass Andrew J, Wallace Chris

Abstract excerpt

The cost of recruiting participants for genome-wide association studies (GWASs) can limit sample sizes and hinder the discovery of genetic variants. Here we introduce the surrogate functional false discovery rate (sfFDR) framework that integrates summary statistics of related traits to increase power. The sfFDR framework provides estimates of FDR quantities such as the functional local FDR and q value, and uses...

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Identifiers

PMID: 40846906
DOI: 10.1038/s43588-025-00852-3
PMCID: PMC12457191

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