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Article

Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.

The Lancet. Respiratory medicine - 1 Mar 2020

Sinha Pratik, Delucchi Kevin L, McAuley Daniel F, O'Kane Cecilia M, Matthay Michael A, Calfee Carolyn S

Abstract excerpt

BACKGROUND: Using latent class analysis (LCA) in five randomised controlled trial (RCT) cohorts, two distinct phenotypes of acute respiratory distress syndrome (ARDS) have been identified: hypoinflammatory and hyperinflammatory. The phenotypes are associated with differential outcomes and treatment response. The objective of this study was to develop parsimonious models for phenotype identification that could be...

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Identifiers

PMID: 31948926
DOI: 10.1016/S2213-2600(19)30369-8
PMCID: PMC7543720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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