Biological subphenotypes in severe acute hypoxaemic respiratory failure and acute respiratory distress syndrome using rapid prospective classification (SPARC) in the USA: a multicentre, observational, study.

doi:10.1016/S2213-2600(26)00083-4

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Article

Biological subphenotypes in severe acute hypoxaemic respiratory failure and acute respiratory distress syndrome using rapid prospective classification (SPARC) in the USA: a multicentre, observational, study.

The Lancet. Respiratory medicine - 1 Jul 2026

Files D Clark, Matthay Michael A, Chapple Andrew G, Barragan Alejandro Botello, Mabrey Linzee, Gibbs Kevin W, Krall Jennifer, Aggarwal Neil R, Burnham Ellen L, Liu Kathleen D, Meyer Nuala J, Nates Joseph L, Youssef Fady A, Friedman Eliot, Kett Daniel H, Koff Jonathan, Russell Derek W, Calfee Carolyn S, Eklund Martin, Esserman Laura J

Abstract excerpt

BACKGROUND: Two biological subphenotypes in acute respiratory distress syndrome (ARDS) have been identified in retrospective analyses, with differential clinical outcomes and post-hoc responses to investigational treatments. The ability to identify biological subphenotypes in real-time is unknown. We aimed to evaluate the feasibility of using the multisite ISPY COVID Network to prospectively evaluate biological...

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PMID: 42140220
DOI: 10.1016/S2213-2600(26)00083-4

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SPARC

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