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Article

PROX1 is an early driver of lineage plasticity in prostate cancer

1 Jun 2025

Abstract excerpt

Lineage plasticity is recognized as a critical determinant of lethality and resistance to AR pathway inhibitors in prostate cancer. Lineage plasticity is a continuum, ranging from AR activity-low tumors, AR-null tumors that do not express a neuroendocrine prostate cancer (NEPC) program (i.e., double-negative prostate cancer [DNPC]), and AR-null NEPC tumors. Factors upregulated early in lineage plasticity are not...

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PMID: 40454483
DOI: 10.1172/jci187490

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