Article
Evolution and Co-occurrence of PI3K Pathway Gene Mutations in Endometrial Carcinoma Molecular Subtypes at the Single-Cell Level.
Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Nov 2025
Da Cruz Paula Arnaud, Zhu Yingjie, Brown David N, Issa Bhaloo Shirin, Pareja Fresia, Hoang Timothy J, Green Hunter, Basili Thais, Dopeso Higinio, Selenica Pier, da Silva Edaise M, Riaz Nadeem, Chandarlapaty Sarat, Abu-Rustum Nadeem R, Reis-Filho Jorge S, Weigelt Britta
Abstract excerpt
PURPOSE: The PI3K pathway is altered in >85% of endometrioid endometrial carcinomas (EEC), with multiple mutations commonly co-occurring. Yet, the therapeutic effects of single-agent PI3K pathway inhibitors have been limited. We used single-cell sequencing to determine whether co-occurring PTEN, PIK3CA, and/or PIK3R1 somatic mutations in EECs stratified by molecular subtype originated through convergent or linear...
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