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From Genes to Clinical Practice: Exploring the Genomic Underpinnings of Endometrial Cancer

20 Jan 2025

Abstract excerpt

Endometrial cancer (EC), a prevalent gynecological malignancy, presents significant challenges due to its genetic complexity and heterogeneity. The genomic landscape of EC is underpinned by genetic alterations, such as mutations in PTEN, PIK3CA, and ARID1A, and chromosomal abnormalities. The identification of molecular subtypes-POLE ultramutated, microsatellite instability (MSI), copy number low, and copy number...

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PMID: 39858102
DOI: 10.3390/cancers17020320

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