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Article

Evolutionary pathways in early-stage, non-myoinvasive endometrioid endometrial cancers of no specific molecular profile.

Gynecologic oncology - 1 Jan 2025

Moufarrij Sara, Lakhman Yulia, Aghajanian Carol, Abu-Rustum Nadeem R, Ellenson Lora H, Weigelt Britta, Momeni-Boroujeni Amir

Abstract excerpt

OBJECTIVE: To characterize the genomic landscape of FIGO 2009 stage IA, non-myometrial invasive endometrioid endometrial cancers (ECs) of no specific molecular profile (NSMP) and define the earliest driver genetic alterations and subsequent tumor evolution. METHODS: Early-stage (FIGO 2009 stage IA), non-myoinvasive endometrioid NSMP ECs subjected to clinical tumor-normal targeted sequencing between 2014 and 2022...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39509805
DOI: 10.1016/j.ygyno.2024.10.029

Genes

PIK3CA
PTEN
ARID1A
KRAS
AKT1
CTNNB1

Provenance

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