Article
Genomic and Immune Landscape of Pancreatic Ductal Adenocarcinoma Associated with Germline Pathogenic Variants in ATM.
Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Nov 2025
Yadav Siddhartha, Bao Riyue, Graham Rondell P, Hu Chunling, Hart Steven N, Na Jie, Boddicker Nicholas, Gnanaolivu Rohan D, Smadbeck James, Ding Li, Billadeau Daniel D, Mayer Aaron T, Majumder Shounak, Morais Lyra Paulo Cilas, Lee Adrian V, Monteiro Alvaro N, Villasboas Jose C, McWilliams Robert, Couch Fergus J
Abstract excerpt
PURPOSE: Germline pathogenic variants (PV) in ATM increase the risk of pancreatic ductal adenocarcinoma (PDAC), but the underlying tumor biology of PDAC associated with germline PV in ATM has not been adequately explored. EXPERIMENTAL DESIGN: Whole-genome, whole-exome, and RNA sequencing were performed on PDAC tumors from 25 germline ATM PV carriers diagnosed at Mayo Clinic between 2007 and 2017. Somatic and...
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- Humans
- Ataxia Telangiectasia Mutated Proteins
- Carcinoma, Pancreatic Ductal