Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical Characteristics of Patients With Pancreatic Cancer and Pathogenic ATM Alterations.

JNCI cancer spectrum - 1 Apr 2021

Hannan Zain, Yu Shun, Domchek Susan, Mamtani Ronac, Reiss Kim A

Abstract excerpt

The Ataxia-Telangiesctasia, mutated (ATM) gene is involved in a number of DNA damage repair pathways and confers an increased risk for pancreatic ductal adenocarcinoma (PDAC). In this retrospective study, we identified and profiled 22 patients with PDAC and a known somatic or germline pathogenic ATM alteration (case patients). These patients were matched 2:1 by age, stage, and year at diagnosis to patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Ataxia Telangiectasia Mutated Proteins
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Confidence Intervals

Share to Germ-Line Mutation

Share to Multivariate Analysis

Share to Mutation

Share to Pancreatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 33733050
DOI: 10.1093/jncics/pkaa121
PMCID: PMC7952223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Characteristics of Patients With Pancreatic Cancer and Pathogenic ATM Alterations.PMID 33733050Read ↗

ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications.Semantic proximity Read ↗

Clinico-genomic Characterization of ATM and HRD in Pancreas Cancer: Application for PracticeSemantic proximity Read ↗

ATM Serine/Threonine Kinase and its Role in Pancreatic RiskSemantic proximity Read ↗

ATM mutations in patients with hereditary pancreatic cancer.Semantic proximity Read ↗

Synchronous Pancreatic Ductal Adenocarcinoma and Nasopharyngeal Carcinoma With Associated Novel Pathogenic ATM Mutation.Semantic proximity Read ↗

Germline Aberrations in Pancreatic Cancer: Implications for Clinical CareSemantic proximity Read ↗

An Emerging Paradigm for Germline Testing in Pancreatic Ductal Adenocarcinoma and Immediate Implications for Clinical Practice: A Review.Semantic proximity Read ↗

Germline Pathogenic Variants in Patients with Pancreatic Ductal Adenocarcinoma and Extra-Pancreatic Malignancies: A Nationwide Database AnalysisSemantic proximity Read ↗

DNA Repair Dysfunction in Pancreatic Cancer: A Clinically Relevant Subtype for Drug Development.Semantic proximity Read ↗

Outcomes in Patients With Pancreatic Adenocarcinoma With Genetic Mutations in DNA Damage Response Pathways: Results From the Know Your Tumor ProgramSemantic proximity Read ↗

Retrospective Survival Analysis of Patients With Advanced Pancreatic Ductal Adenocarcinoma and Germline BRCA or PALB2 MutationsSemantic proximity Read ↗

Effect of Germline Mutations in Homologous Recombination Repair Genes on Overall Survival of Patients with Pancreatic AdenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.