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Clinico-genomic Characterization of ATM and HRD in Pancreas Cancer: Application for Practice

30 Aug 2022

Abstract excerpt

PURPOSE: Characterizing germline and somatic ATM variants (gATMm, sATMm) zygosity and their contribution to homologous recombination deficiency (HRD) is important for therapeutic strategy in pancreatic ductal adenocarcinoma (PDAC). EXPERIMENTAL DESIGN: Clinico-genomic data for patients with PDAC and other cancers with ATM variants were abstracted. Genomic instability scores (GIS) were derived from ATM-mutant...

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PMID: 36040493
DOI: 10.1158/1078-0432.ccr-22-1483

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