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Prevalence and impact of germline mutations in pancreatic ductal adenocarcinoma.

Tumori - 1 Jun 2026

Kahraman Emir Gokhan, Taskaynatan Halil, Özdemir Taha Reşid, Özer Kaya Özge, Keşan Selcan, Ünal Olcun Ümit

Abstract excerpt

BACKGROUND: Germline pathogenic variants are increasingly recognized as critical determinants of pancreatic ductal adenocarcinoma (PDAC) susceptibility, prognosis, and response to targeted therapies such as PARP inhibitors. Recent guidelines recommend germline testing for all PDAC patients, regardless of family history, to identify hereditary cancer syndromes and guide treatment decisions. However, data from...

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BRCA1 Protein
BRCA2 Protein
Carcinoma, Pancreatic Ductal
Genetic Testing
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

Pancreatic Neoplasms

Source

Identifiers

PMID: 41568754
DOI: 10.1177/03008916251410475

Genes

ATM
BRCA1
BRCA2
CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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