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Article

Confirmation of BIK and SAMHD1 as Prostate Cancer Susceptibility Genes.

The Prostate - 1 Dec 2025

Pavlovich Christian P, Wei Jun, Gielzak Marta, Shi Zhuqing, Tran Huy, Ashworth Annabelle, Lilly Zheng S, Walsh Patrick C, Luo Jun, Helfand Brian T, Isaacs William B, Xu Jianfeng

Abstract excerpt

BACKGROUND: To independently assess data for recently reported genes-BIK, SAMHD1, FAM111A, and AOX1-in which rare variants have been associated with prostate cancer (PCa) risk and aggressiveness. METHODS: The study included 4448 PCa cases from Johns Hopkins School of Medicine and 103,221 population-based controls from the Genome Aggregation Database (gnomAD). Gene-based and variant-based association tests were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40825105
DOI: 10.1002/pros.70037
PMCID: PMC12603878

Genes

BIK
SAMHD1
AOX1
HOXB13
CHEK2
FAM111A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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