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Article

Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk.

PloS one - 1 Jan 2008

Ding Yan, Larson Garrett, Rivas Guillermo, Lundberg Cathryn, Geller Louis, Ouyang Ching, Weitzel Jeffrey, Archambeau John, Slater Jerry, Daly Mary B, Benson Al B, Kirkwood John M, O'Dwyer Peter J, Sutphen Rebecca, Stewart James A, Johnson David, Nordborg Magnus, Krontiris Theodore G

Abstract excerpt

Previously, a candidate gene linkage approach on brother pairs affected with prostate cancer identified a locus of prostate cancer susceptibility at D3S1234 within the fragile histidine triad gene (FHIT), a tumor suppressor that induces apoptosis. Subsequent association tests on 16 SNPs spanning approximately 381 kb surrounding D3S1234 in Americans of European descent revealed significant evidence of association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18953408
DOI: 10.1371/journal.pone.0003533
PMCID: PMC2568805

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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