Article
Large-scale fine mapping of the HNF1B locus and prostate cancer risk.
Human molecular genetics - 15 Aug 2011
Berndt Sonja I, Sampson Joshua, Yeager Meredith, Jacobs Kevin B, Wang Zhaoming, Hutchinson Amy, Chung Charles, Orr Nick, Wacholder Sholom, Chatterjee Nilanjan, Yu Kai, Kraft Peter, Feigelson Heather Spencer, Thun Michael J, Diver W Ryan, Albanes Demetrius, Virtamo Jarmo, Weinstein Stephanie, Schumacher Fredrick R, Cancel-Tassin Geraldine, Cussenot Olivier, Valeri Antoine, Andriole Gerald L, Crawford E David, Haiman Christopher, Henderson Brian, Kolonel Laurence, Le Marchand Loic, Siddiq Afshan, Riboli Elio, Travis Ruth C, Kaaks Rudolf, Isaacs William, Isaacs Sarah, Wiley Kathleen E, Gronberg Henrik, Wiklund Fredrik, Stattin Pär, Xu Jianfeng, Zheng S Lilly, Sun Jielin, Vatten Lars J, Hveem Kristian, Njølstad Inger, Gerhard Daniela S, Tucker Margaret, Hayes Richard B, Hoover Robert N, Fraumeni Joseph F, Hunter David J, Thomas Gilles, Chanock Stephen J
Abstract excerpt
Previous genome-wide association studies have identified two independent variants in HNF1B as susceptibility loci for prostate cancer risk. To fine-map common genetic variation in this region, we genotyped 79 single nucleotide polymorphisms (SNPs) in the 17q12 region harboring HNF1B in 10 272 prostate cancer cases and 9123 controls of European ancestry from 10 case-control studies as part of the Cancer Genetic...
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