Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer.

doi:10.1158/1078-0432.CCR-18-0444

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2018

Sipeky Csilla, Gao Ping, Zhang Qin, Wang Liang, Ettala Otto, Talala Kirsi M, Tammela Teuvo L J, Auvinen Anssi, Wiklund Fredrik, Wei Gong-Hong, Schleutker Johanna

Abstract excerpt

PURPOSE: Distinguishing aggressive prostate cancer from indolent disease improves personalized treatment. Although only few genetic variants are known to predispose to aggressive prostate cancer, synergistic interactions of HOXB13 G84E high-risk prostate cancer susceptibility mutation with other genetic loci remain unknown. The purpose of this study was to examine the interplay of HOXB13 rs138213197 (G84E) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Germ-Line Mutation

Share to Intracellular Signaling Peptides and Proteins

Share to Kaplan-Meier Estimate

Share to Neoplasm Grading

Share to Neoplasm Staging

Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 30181389
DOI: 10.1158/1078-0432.CCR-18-0444
PMCID: PMC6719560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer.PMID 30181389Read ↗

Prostate cancer risk variants of the HOXB genetic locus.Semantic proximity Read ↗

Prevalence of the HOXB13 G84E mutation in Danish men undergoing radical prostatectomy and its correlations with prostate cancer risk and aggressiveness.Semantic proximity Read ↗

A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility.Semantic proximity Read ↗

HOXB13, a high-risk prostate cancer gene, also confers risk for breast cancer: novel variants of clinical significance, especially in hormone-positive patients.Semantic proximity Read ↗

G84E mutation in HOXB13 is firmly associated with prostate cancer risk: a meta-analysis.Semantic proximity Read ↗

Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer.Semantic proximity Read ↗

Association between germline homeobox B13 (HOXB13) G84E allele and prostate cancer susceptibility: a meta-analysis and trial sequential analysis.Semantic proximity Read ↗

HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease.Semantic proximity Read ↗

HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG).Semantic proximity Read ↗

HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.Semantic proximity Read ↗

HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directionsSemantic proximity Read ↗

Association of HOXB13 G84E With Prostate Cancer Among 592,158 Men.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.