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Article

The HOXB13 variant X285K is associated with clinical significance and early age at diagnosis in African American prostate cancer patients.

British journal of cancer - 1 Mar 2022

Na Rong, Wei Jun, Sample Chris J, Gielzak Marta, Choi Sodam, Cooney Kathleen A, Rabizadeh Daniel, Walsh Patrick C, Zheng Lilly S, Xu Jianfeng, Isaacs William B

Abstract excerpt

BACKGROUND: Recently, a novel HOXB13 variant (X285K) was observed in men of African descent with prostate cancer (PCa) in Martinique. Little is known about this or other variants in HOXB13 which may play a role in PCa susceptibility in African-American (AA) men. METHODS: We sequenced HOXB13 in an AA population of 1048 men undergoing surgical treatment for PCa at Johns Hopkins Hospital. RESULTS: Seven...

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Identifiers

PMID: 34799695
DOI: 10.1038/s41416-021-01622-4
PMCID: PMC8888559

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