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Article

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer.

Oncotarget - 15 Nov 2016

Ross-Adams Helen, Ball Stephen, Lawrenson Kate, Halim Silvia, Russell Roslin, Wells Claire, Strand Siri H, Ørntoft Torben F, Larson Melissa, Armasu Sebastian, Massie Charles E, Asim Mohammad, Mortensen Martin M, Borre Michael, Woodfine Kathryn, Warren Anne Y, Lamb Alastair D, Kay Jonathan, Whitaker Hayley, Ramos-Montoya Antonio, Murrell Adele, Sørensen Karina D, Fridley Brooke L, Goode Ellen L, Gayther Simon A, Masters John, Neal David E, Mills Ian G

Abstract excerpt

Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated HNF1B gene expression and allele-specific epigenetic silencing, and outline a mechanism by which common risk variants could effect functional changes that increase...

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Share to Cell Movement
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Source

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Identifiers

PMID: 27732966
DOI: 10.18632/oncotarget.12543
PMCID: PMC5342698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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