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Article

Mutant p53 affects the mitochondrial proteome, promoting mitochondrial fragmentation and OXPHOS in pancreatic ductal adenocarcinoma cells.

The FEBS journal - 1 Jan 2026

Poles Maria, Pacchiana Raffaella, Mortali Chiara, Cisterna Barbara, Mullappilly Nidula, Celesia Adriana, Danzi Federica, Gaspari Martina, Cecconi Daniela, Donadelli Massimo, Fiore Alessandra

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer marked by poor prognosis and frequent gain-of-function mutations in the TP53 tumor suppressor gene. Given the crucial role of mutant p53 in the context of metabolic reprogramming and aggressive tumor behavior, we explored its role on mitochondria, which may present a valuable therapeutic target. In this study, we characterized the unique...

Read the complete abstract on PubMed

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Share to Carcinoma, Pancreatic Ductal
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Myosin Heavy Chains

Share to Oxidative Phosphorylation

Share to Pancreatic Neoplasms

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 40819215
DOI: 10.1111/febs.70223

Genes

MYH14
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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