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Article

Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNA.

Autophagy - 1 Nov 2016

Malena Adriana, Pantic Boris, Borgia Doriana, Sgarbi Gianluca, Solaini Giancarlo, Holt Ian J, Spinazzola Antonella, Perissinotto Egle, Sandri Marco, Baracca Alessandra, Vergani Lodovica

Abstract excerpt

Pathological mutations in the mitochondrial DNA (mtDNA) produce a diverse range of tissue-specific diseases and the proportion of mutant mitochondrial DNA can increase or decrease with time via segregation, dependent on the cell or tissue type. Previously we found that adenocarcinoma (A549.B2) cells favored wild-type (WT) mtDNA, whereas rhabdomyosarcoma (RD.Myo) cells favored mutant (m3243G) mtDNA. Mitochondrial...

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Identifiers

PMID: 27627835
DOI: 10.1080/15548627.2016.1226734
PMCID: PMC5103342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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