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Discovery of Mieap‐regulated mitochondrial quality control as a new function of tumor suppressor p53

21 Feb 2017

Abstract excerpt

The tumor suppressor p53 gene is frequently mutated in human cancers, and the p53 protein suppresses cancer. However, the mechanism behind the p53‐mediated tumor suppression is still unclear. Recently, the mitochondria‐eating protein (Mieap) was identified as a p53‐inducible protein. Mieap induces the accumulation of lysosomal proteins within mitochondria (Mieap‐induced accumulation of lysosome‐like organelles...

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PMID: 28222492
DOI: 10.1111/cas.13208

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