Learning antibody sequence constraints from allelic inclusion.

Abstract excerpt

Although antibody sequences are highly diverse, they are constrained by requirements for expression and limited off-target reactivity. Describing which sequences violate such constraints has proven to be difficult. Here, we introduce a machine-learning framework to leverage a previously underutilized source of data for this problem. We use human single-cell sequencing data to find instances of allelic inclusion,...

Topics

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• Share to Alleles
• Share to Antibodies
• Share to B-Lymphocytes