Looking for Therapeutic Antibodies in Next Generation Sequencing Repositories

Abstract excerpt

Recently it has become possible to query the great diversity of natural antibody repertoires using Next Generation Sequencing (NGS). These methods are capable of producing millions of sequences in a single experiment. Here we compare Clinical Stage Therapeutic antibodies to the ∼1b sequences from 60 independent sequencing studies in the Observed Antibody Space Database. Of the 242 post Phase I antibodies, we find...

Topics

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• Biosimilars and Bioanalytical Methods
• Chronic Lymphocytic Leukemia Research
• Glycosylation and Glycoproteins Research
• HIV Research and Treatment
• Monoclonal and Polyclonal Antibodies Research
• RNA and protein synthesis mechanisms
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

6e05b28d-fd55-5e31-be5a-5f9e667baf2b

DOI

10.1101/572958