Learning antibody sequence constraints from allelic inclusion

Abstract excerpt

Antibodies and B-cell receptors (BCRs) are produced by B cells, and are built of a heavy chain and a light chain. Although each B cell could express two different heavy chains and four different light chains, usually only a unique pair of heavy chain and light chain is expressed—a phenomenon known as allelic exclusion . However, a small fraction of naive-B cells violate allelic exclusion by expressing two product...

Topics

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• Alleles
• Antibodies
• B-Lymphocytes
• Immunoglobulin Heavy Chains
• Immunoglobulin Light Chains
• Machine Learning
• Mice
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

948c63a8-a5e6-521d-a767-57e743751038

DOI

10.1101/2024.10.22.619760