Article
When ribosomes go bad: diseases of ribosome biogenesis.
Molecular bioSystems - 1 Mar 2010
Freed Emily F, Bleichert Franziska, Dutca Laura M, Baserga Susan J
Abstract excerpt
Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of these complexes. However, in the last few decades, a number of diseases of ribosome biogenesis have been discovered. It remains a challenge in the field to elucidate the molecular mechanisms underlying them.
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