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Ribosome biogenesis: A central player in liver diseases

5 Jan 2025

Abstract excerpt

Ribosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining liver function. In eukaryotes, it involves producing and assembling approximately 200 factors and 80 ribosomal proteins. Mutations in ribosome proteins, ribosomal RNA processing, and ribosome assembly factors in...

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PMID: 40521004
DOI: 10.1016/j.gendis.2025.101512

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