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Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing

13 Aug 2025

Abstract excerpt

Acute myeloid leukemia (AML) originates in the bone marrow (BM), but in some patients, leukemic cells infiltrate peripheral tissues such as the skin ( leukemia cutis ) or other organs ( myeloid sarcoma ), a phenomenon known as extramedullary AML (eAML). eAML can present at initial diagnosis, during relapse after chemotherapy or allogeneic hematopoietic cell transplantation (allo-HCT), either in isolation or...

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PMID: 40804254
DOI: 10.1038/s41408-025-01345-2

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