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Article

Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2019

Kim Juhan, Flood Jake J, Kristofich Michael R, Gidfar Cyrus, Morgenthaler Andrew B, Fuhrer Tobias, Sauer Uwe, Snyder Daniel, Cooper Vaughn S, Ebmeier Christopher C, Old William M, Copley Shelley D

Abstract excerpt

PdxB (erythronate 4-phosphate dehydrogenase) is expected to be required for synthesis of the essential cofactor pyridoxal 5'-phosphate (PLP) in Escherichia coli Surprisingly, incubation of the ∆pdxB strain in medium containing glucose as a sole carbon source for 10 d resulted in visible turbidity, suggesting that PLP is being produced by some alternative pathway. Continued evolution of parallel lineages for 110...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 31712440
DOI: 10.1073/pnas.1915569116
PMCID: PMC6883840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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