Article
miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018
Møller Rasmus, Schwarz Toni M, Noriega Vanessa M, Panis Maryline, Sachs David, Tortorella Domenico, tenOever Benjamin R
Abstract excerpt
Human cytomegalovirus (HCMV) impacts more than one-half of the human population owing to its capacity to manipulate the cell and create latent reservoirs in the host. Despite an extensive understanding of HCMV biology during acute infection in fibroblasts, the molecular basis for latency in myeloid cells remains incomplete. This knowledge gap is due largely to the fact that the existing genetic systems require...
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