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Article

Excised DNA circles from V(D)J recombination promote relapsed leukaemia.

Nature - 1 Sept 2025

Gao Zeqian, Scott James N F, Edwards Matthew P, Casey Dylan, Wang Xiaoling, Gillen Andrew D, Ryan Sarra, Russell Lisa J, Moorman Anthony V, de Tute Ruth, Cargo Catherine, Ford Anthony M, Westhead David R, Boyes Joan

Abstract excerpt

Extrachromosomal DNA amplification is associated with poor cancer prognoses1. Large numbers of excised signal circles (ESCs) are produced as by-products of antigen receptor rearrangement during V(D)J recombination2,3. However, current dogma states that ESCs are progressively lost through cell division4. Here we show that ESCs replicate and persist through many cell generations and share many properties in...

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Identifiers

PMID: 40770098
DOI: 10.1038/s41586-025-09372-6
PMCID: PMC12443594

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