Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies

9 May 2013

Abstract excerpt

T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are circular DNA segments generated in T and B cells during their maturation in the thymus and bone marrow. These circularized DNA elements persist in the cells, are unable to replicate, and are diluted as a result of cell division, thus are considered markers of new lymphocyte output. The quantification of TRECs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23656963
DOI: 10.1186/1479-5876-11-119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficienciesPMID 23656963Read ↗

PID Comes Full Circle: Applications of V(D)J Recombination Excision Circles in Research, Diagnostics and Newborn Screening of Primary Immunodeficiency DisordersSemantic proximity Read ↗

TREC and KREC profiling as a representative of thymus and bone marrow output in patients with various inborn errors of immunity.Semantic proximity Read ↗

Utility of simultaneous quantification of TREC/KREC in patients with common variable immunodeficiency phenotype: an observational study from North India.Semantic proximity Read ↗

Investigating the Variation of TREC/KREC in Combined Immunodeficiencies.Semantic proximity Read ↗

Newborn Screening for Primary Immunodeficiency Diseases: History, Current and Future PracticeSemantic proximity Read ↗

Neonatal screening for severe primary immunodeficiency diseases using high-throughput triplex real-time PCRSemantic proximity Read ↗

Retrospective analysis of TREC based newborn screening results and clinical phenotypes in infants with the 22q11 deletion syndrome.Semantic proximity Read ↗

Newborn Screening for Severe Primary Immunodeficiency Diseases in Sweden-a 2-Year Pilot TREC and KREC Screening Study.Semantic proximity Read ↗

Case report: IKZF1-related early-onset CID is expected to be missed in TREC-based SCID screening but can be identified by determination of KREC levels.Semantic proximity Read ↗

Long-lasting production of new T and B cells and T-cell repertoire diversity in patients with primary immunodeficiency who had undergone stem cell transplantation: a single-centre experience.Semantic proximity Read ↗

Genomic-Based Newborn Screening for Inborn Errors of Immunity: Practical and Ethical ConsiderationsSemantic proximity Read ↗

Primary immunodeficiency update and newborn screening.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.