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Article

Chromosomal reinsertion of broken RSS ends during T cell development.

The Journal of experimental medicine - 1 Oct 2007

Curry John D, Schulz Danae, Guidos Cynthia J, Danska Jayne S, Nutter Lauryl, Nussenzweig Andre, Schlissel Mark S

Abstract excerpt

The V(D)J recombinase catalyzes DNA transposition and translocation both in vitro and in vivo. Because lymphoid malignancies contain chromosomal translocations involving antigen receptor and protooncogene loci, it is critical to understand the types of "mistakes" made by the recombinase. Using a newly devised assay, we characterized 48 unique TCRbeta recombination signal sequence (RSS) end insertions in murine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Mice, Knockout

Share to Recombination, Genetic

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Source

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Identifiers

PMID: 17785508
DOI: 10.1084/jem.20070583
PMCID: PMC2118463

Genes

RAG2
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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