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Article

Rodent models of the human isoniazid-acetylator polymorphism.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Tannen R H, Weber W W

Abstract excerpt

Inbred strains and subpopulations of rats, laboratory mice, and deer mice were examined for individual variation in the ability to metabolize several arylamines (p-aminobenzoic acid, sulfamethazine, aniline, alpha-naphthylamine, and aminofluorene) by N-acetylation. Individual differences within species were found to be dependent upon the tissue source of N-acetyltransferase activity and the acetyl acceptor...

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PMID: 40765

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