Article
Rodent models of the human isoniazid-acetylator polymorphism.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Tannen R H, Weber W W
Abstract excerpt
Inbred strains and subpopulations of rats, laboratory mice, and deer mice were examined for individual variation in the ability to metabolize several arylamines (p-aminobenzoic acid, sulfamethazine, aniline, alpha-naphthylamine, and aminofluorene) by N-acetylation. Individual differences within species were found to be dependent upon the tissue source of N-acetyltransferase activity and the acetyl acceptor...
Topics
- Acetylation
- Animals
- Isoniazid
- Liver
- Mice
- Mice, Inbred A
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Models, Biological
- Peromyscus
- Phenotype