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Article

Downregulation of NOTCH1 and NOTCH4 signalling influences the modulation of schizophrenia onset.

Psychiatric genetics - 1 Oct 2025

Talukdar Uddip, Bharali Abhijit, Kakoty Swapna D, Choudhury Chayanika, Talukdar Ramen, Das Partha Pratim

Abstract excerpt

BACKGROUND: Schizophrenia is a chronic neuropsychiatric disorder characterised by a range of positive and negative symptoms. The genetic aspect of schizophrenia is highly pleiotropic, as the complete set of neurodevelopmental factors contributing to the onset of the disease has yet to be fully identified. The Notch signalling pathway is increasingly recognised as a key player in the neurodevelopmental processes,...

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Source

Identifiers

PMID: 40762421
DOI: 10.1097/YPG.0000000000000400

Genes

NOTCH4
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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