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Methylation profile of individuals with sickle cell trait

4 Aug 2025

Abstract excerpt

Sickle cell trait (SCT) is due to heterozygosity for the β-globin sickle cell mutation. SCT recently has been associated with increased risk of various adverse health outcomes. DNA methylation (DNAm) is one potential mechanism by which SCT may impact disease risk. To identify DNAm sites associated with SCT, we conducted an epigenome-wide association (EWAS) meta-analysis using whole blood Illumina EPIC array data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40758858
DOI: 10.1080/15592294.2025.2539234

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