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Article

Genome-wide association study of erythrocyte density in sickle cell disease patients.

Blood cells, molecules & diseases - 1 Jun 2017

Ilboudo Yann, Bartolucci Pablo, Rivera Alicia, Sedzro Josepha-Clara, Beaudoin Mélissa, Trudel Marie, Alper Seth L, Brugnara Carlo, Galactéros Frédéric, Lettre Guillaume

Abstract excerpt

Deoxy-hemoglobin S polymerization into rigid fibers is the direct cause of the clinical sequelae observed in sickle cell disease (SCD). The rate of polymerization of sickle hemoglobin is determined primarily by intracellular hemoglobin concentration, itself dependent on the amount of sickle hemoglobin and on red blood cell (RBC) volume. Dense, dehydrated RBC (DRBC) are observed in SCD patients, and their number...

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Source

Identifiers

PMID: 28552477
DOI: 10.1016/j.bcmd.2017.05.005

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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