Article

Stochastic Epigenetic Mutations: Reliable Detection and Associations with Cardiovascular Aging

2023-12-13

Abstract excerpt

<h4>ABSTRACT</h4> Stochastic Epigenetic Mutations (SEMs) have been proposed as novel aging biomarkers that have the potential to capture heterogeneity in age-related DNA methylation (DNAme) changes. SEMs are defined as outlier methylation patterns at cytosine-guanine dinucleotide (CpG) sites, categorized as hypermethylated (hyperSEM) or hypomethylated (hypoSEM) relative to a reference. While individual SEMs are r...

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Literature Corpus work: 9ae16fa4-0604-5d57-a2e9-402995638bf8
DOI: 10.1101/2023.12.12.571149

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