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Characterizing epigenetic aging in an adult sickle cell disease cohort

15 Nov 2023

Abstract excerpt

ABSTRACT: Sickle cell disease (SCD) affects ∼100 000 predominantly African American individuals in the United States, causing significant cellular damage, increased disease complications, and premature death. However, the contribution of epigenetic factors to SCD pathophysiology remains relatively unexplored. DNA methylation (DNAm), a primary epigenetic mechanism for regulating gene expression in response to the...

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PMID: 37967379
DOI: 10.1182/bloodadvances.2023011188

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