Characterisation of a persistent SARS-CoV-2 infection lasting more than 750 days in a person living with HIV: a genomic analysis.

doi:10.1016/j.lanmic.2025.101122

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Article

Characterisation of a persistent SARS-CoV-2 infection lasting more than 750 days in a person living with HIV: a genomic analysis.

The Lancet. Microbe - 1 Sept 2025

Velasquez-Reyes Joseline M, Schaeffer Beau, Curry Scott R, Overbeck Victoria, Sher-Jan Cole, Taylor Bradford P, Turcinovic Jacquelyn, Kuppalli Krutika, Connor John H, Hanage William P

Abstract excerpt

BACKGROUND: People who are immunocompromised can develop persistent SARS-CoV-2 infections. Several viral mutations accumulated during the course of such persistent infections have also been observed in prominent variants of concern (VOCs). Here, we characterise persistent infection and viral evolution of SARS-CoV-2 lasting more than 750 days in a person with advanced HIV-1 infection. METHODS: Between March, 2021,...

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Topics

Humans
COVID-19
SARS-CoV-2
HIV Infections
Genome, Viral
Phylogeny

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Male

Persistent Infection

Genomics

RNA, Viral

Evolution, Molecular

Middle Aged

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 40706602
DOI: 10.1016/j.lanmic.2025.101122
PMCID: PMC12633830

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