Article
The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp.
eLife - 6 Jul 2023
Rosas Natalia C, Wilksch Jonathan, Barber Jake, Li Jiahui, Wang Yanan, Sun Zhewei, Rocker Andrea, Webb Chaille T, Perlaza-Jiménez Laura, Stubenrauch Christopher J, Dhanasekaran Vijaykrishna, Song Jiangning, Taiaroa George, Davies Mark, Strugnell Richard A, Bao Qiyu, Zhou Tieli, McDonald Michael J, Lithgow Trevor
Abstract excerpt
Antibiotic resistance is driven by selection, but the degree to which a bacterial strain's evolutionary history shapes the mechanism and strength of resistance remains an open question. Here, we reconstruct the genetic and evolutionary mechanisms of carbapenem resistance in a clinical isolate of Klebsiella quasipneumoniae. A combination of short- and long-read sequencing, machine learning, and genetic and...
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