Article
Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract.
Cancer communications (London, England) - 1 Dec 2022
Wu Huanwen, Yu Zicheng, Liu Yueping, Guo Lei, Teng Lianghong, Guo Lingchuan, Liang Li, Wang Jing, Gao Jie, Li Ruiyu, Yang Ling, Nie Xiu, Su Dan, Liang Zhiyong
Abstract excerpt
BACKGROUND: Neuroendocrine carcinomas of the gastrointestinal tract (GI-NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI-NECs. METHODS: Comprehensive genomic analysis using whole-exome sequencing was performed on 143 formalin-fixed, paraffin-embedded...
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