Molecular-clinical characteristics and treatment outcomes in 163 metastatic colorectal neuroendocrine carcinomas with a comparison to colorectal adenocarcinomas.

doi:10.1002/ijc.70367

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Article

Molecular-clinical characteristics and treatment outcomes in 163 metastatic colorectal neuroendocrine carcinomas with a comparison to colorectal adenocarcinomas.

International journal of cancer - 15 Jun 2026

Morken Siren, Langer Seppo W, Hjortland Geir Olav, Sundlöv Anna, Hofsli Eva, Ladekarl Morten, Tabaksblat Elizaveta, Vestermark Lene Weber, Svensson Johanna, Knigge Ulrich, Nunes Luís, Glimelius Bengt, Pfeiffer Per, Aasebø Kristine, Assmus Jörg, Vassella Erik, Lothe Inger Marie Bowitz, Couvelard Anne, Perren Aurel, Knappskog Stian, Sorbye Halfdan

Abstract excerpt

There is limited data regarding the rare and aggressive colorectal neuroendocrine carcinoma (CR-NEC). In this large prospective study, molecular-clinical characteristics and treatment outcomes following palliative chemotherapy are reported for 163 metastatic CR-NEC patients, with a comparison to a population-based prospective cohort of 263 metastatic colorectal adenocarcinoma (CR-AC) patients. Eighty-three...

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PMID: 41642024
DOI: 10.1002/ijc.70367
PMCID: PMC13106932

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APC
BRAF
KRAS
TP53

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