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Article

A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis.

Disease models & mechanisms - 1 Jan 2013

Speakman John R, Westerterp Klaas R

Abstract excerpt

The thrifty-gene hypothesis (TGH) posits that the modern genetic predisposition to obesity stems from a historical past where famine selected for genes that promote efficient fat deposition. It has been previously argued that such a scenario is unfeasible because under such strong selection any gene favouring fat deposition would rapidly move to fixation. Hence, we should all be predisposed to obesity: which we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22864023
DOI: 10.1242/dmm.010009
PMCID: PMC3529354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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