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Article

Lessons from extreme human obesity: monogenic disorders.

Endocrinology and metabolism clinics of North America - 1 Sept 2008

Ranadive Sayali A, Vaisse Christian

Abstract excerpt

Human obesity has a strong genetic component. Most genes that influence an individual's predisposition to gain weight are not yet known. However, the study of extreme human obesity caused by single gene defects has provided a glimpse into the long-term regulation of body weight. These monogenic obesity disorders have confirmed that the hypothalamic leptin-melanocortin system is critical for energy balance in...

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Identifiers

PMID: 18775361
DOI: 10.1016/j.ecl.2008.07.003
PMCID: PMC5877402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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