Article

Detecting Monogenic Obesity: A Systematic Exome-Wide Workup of Over 500 Individuals

2025-02-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background/Objectives</h4> Obesity poses a major public health concern. Although BMI heritability is estimated at 40–80%, genetic diagnostics remain challenging. This study aims to ( i ) assess the diagnostic yield of monogenic obesity in a large patient sample using exome-wide data, ( ii ) identify predictors to improve genetic testing criteria, and ( iii ) evaluate whether the identifi...

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Literature Corpus work: 7151ef5c-06cb-54f7-a7d8-1e08a57a45ca
DOI: 10.1101/2025.02.19.25322216

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