Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer.

Nature immunology - 1 Sept 2025

Xiang Chen, Park Ann Y, Weber Sarah E, Lenardo Michael J, Ozen Ahmet, Cui Jing

Abstract excerpt

Inborn errors of immunity (IEIs) are rare genetic anomalies that cause defective immune function. Over 500 IEIs have been identified to date, affecting millions of patients globally. These IEIs reveal the complex interplay between genetics, the environment and microorganisms that determine immune disease phenotypes. Progress in understanding the molecular and cellular mechanisms of IEIs provides a genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to Genetic Diseases, Inborn
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immune responses and vaccinations

Share to Immunodeficiency and Autoimmune Disorders

Share to Inflammatory Bowel Diseases

Share to Neoplasms

Share to SARS-CoV-2

Source

Identifiers

PMID: 40721512
DOI: 10.1038/s41590-025-02225-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer.PMID 40721512Read ↗

Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19?Semantic proximity Read ↗

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19.Semantic proximity Read ↗

Malignancy and Autoimmune Susceptibility in Adult Patients with Human Inborn Errors of Immunity.Semantic proximity Read ↗

COVID-19 infection in inborn errors of immunity and their phenocopies: a systematic review and meta-analysis.Semantic proximity Read ↗

Immunogenetics of Gastrointestinal Cancers: A Systematic Review of Inborn Errors of Immunity in HumansSemantic proximity Read ↗

Rare variants in inborn errors of immunity genes in young adults with severe COVID-19: Insights from a Brazilian cohort.Semantic proximity Read ↗

The Role of Immunogenetics in COVID-19.Semantic proximity Read ↗

Genetic risk factors for serious infections in inflammatory bowel diseases.Semantic proximity Read ↗

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification.Semantic proximity Read ↗

Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.Semantic proximity Read ↗

Variants in Interferon Lambda are Associated with Very Early Onset Inflammatory Bowel DiseaseSemantic proximity Read ↗

COVID-19 Impact in Crohn’s Disease Patients Underwent Autologous Hematopoietic Stem Cell TransplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.