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Article

Malignancy and Autoimmune Susceptibility in Adult Patients with Human Inborn Errors of Immunity.

Journal of clinical immunology - 30 Sept 2025

Segura-Tudela Alejandro, Nieto-López Celia, Bermejo-Olivera Francisco Javier, Andara Luis A, Arroyo-Ródenas Javier, Dueñas-Prieto Lucía, Alfocea-Molina Ángel, Paz-Artal Estela, Pleguezuelo Daniel, Cabrera-Marante Oscar, Allende Luis M

Abstract excerpt

Inborn errors of immunity (IEI) are a heterogeneous group of genetic disorders that disrupt the normal development and function of the immune system. These diseases not only increase susceptibility to infections but also significantly elevate the risk of developing malignancies and autoimmune diseases. The interplay between immune dysregulation, chronic inflammation, and altered cellular homeostasis in IEI can...

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Identifiers

PMID: 41026241
DOI: 10.1007/s10875-025-01935-6
PMCID: PMC12484250

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