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Rare variants in inborn errors of immunity genes in young adults with severe COVID-19: Insights from a Brazilian cohort.

Human immunology - 1 Jul 2026

Barros de Oliveira Sá Marcus Villander, Rocha Gabriela Dias, Silveira Oliveira Pablo Rafael, Campos Túlio de Lima, Lisbôa Furtado Guilherme Torres, Galdino Galisa Steffany Larissa, Silva Andreia Soares, Moura Patricia, São Pedro Raquel Bispo de, Tavares Natália Machado, Boaventura Viviane Sampaio, Nunes Sara, Bonyek-Silva Icaro, Caldas Juliana Ribeiro, Roma Eric Henrique, Almeida Jorge Reis, Silva Andrea Alice, Baccin Tatiana, Castro Andrea Cauduro de, Rosario Vallinoto Antônio Carlos, da Silva Rosilene, Melo Dos Santos Eduardo José, Garcia Cristiana Couto, Slhessarenko Renata Dezengrini, Armstrong Anderson da Costa, Carmo Rodrigo Feliciano, Silva Vasconcelos Luydson Richardson

Abstract excerpt

BACKGROUND: Host genetic variability, particularly involving inborn errors of immunity (IEI), has emerged as a critical determinant of interindividual differences in COVID-19 severity, yet comprehensive genomic characterization of IEI-related variants in admixed Latin American populations remains scarce. OBJECTIVE: To characterize rare pathogenic variants in IEI-related genes among previously healthy young...

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Identifiers

PMID: 42190421
DOI: 10.1016/j.humimm.2026.111764

Genes

MVK
CARD9
CFTR
ELANE
FANCA
PMS2
TCIRG1
TGFBR1
TPP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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