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Article

Genetic and computational analysis of AKR1C4 gene rs17134592 polymorphism in breast cancer among the Bangladeshi population.

Scientific reports - 28 Jul 2025

Shaon Md Akeruzzaman, Ansari Farzana, Mahmud Zimam, Tamanna Sonia, Al Saba Abdullah, Sikder Rushafi, Howlader Tabassum, Howlader Md Zakir Hossain

Abstract excerpt

Breast cancer is characterized by the unchecked proliferation of breast cells. Variations in the metabolism of steroid hormones can influence the risk of this disease by modifying the concentration and the potency of these hormones. The enzyme AKR1C4, primarily found in the liver, is crucial for regulating these hormone levels in the bloodstream. This research examined the relationship between a polymorphic...

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Identifiers

PMID: 40721470
DOI: 10.1038/s41598-025-13411-7
PMCID: PMC12304218

Genes

AKR1C4

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